FIELD : medicine.SUBSTANCE : invention relates to the field of medicine, pharmacology, namely to a new pharmaceutical combination of flupirtine and cyclobenzaprine, or their pharmaceutically acceptable salts.EFFECT : invention is intended for the treatment of pain syndromes, including pain associated with static and functional diseases of the spine; pain syndrome after injuries and surgical interventions; pain associated with skeletal muscle spasticity; pain associated with a malignant process; headache; dysmenorrhea and algodismenorrhea.9 cl, 8 tbl, 8 ex