| 专利名称 | For the treatment of inflammatory diseases of the benzimidazole derivative and its medicinal composition | ||
| 申请号 | JP2016548110 | 申请日 | |
| 公开(公告)号 | JP6472454B2 | 公开(公告)日 | 2015-01-19 |
| 申请(专利权)人 | 发明人 | クリステル ジェアンネ マリエ メネト; オスカル マムモリティ; ジャビエル ブランク; ミスラブ オルスリク; マジャ ロスシス | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention discloses compounds according to Formula I : Wherein Cy, R 1 , L 1 , R 3 , R 4 , R 5 , L a , and R a are as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons. |
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