| 专利名称 | NEUROPROTECTIVE MEANS, HAVING THE PROPERTIES OF ANTIOXIDANT AND NITRIC OXIDE DONATOR | ||
| 申请号 | RU2016127070 | 申请日 | |
| 公开(公告)号 | RU2680526C1 | 公开(公告)日 | 2016-07-05 |
| 申请(专利权)人 | 发明人 | Shchepetkin Igor Aleksandrovich; Atochin Dmitrij Nikolaevich; Khlebnikov Andrej Ivanovich; Plotnikov Mark Borisovich; Chernysheva Galina Anatolevna; Smolyakova Vera Ivanovna | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
FIELD : medicine.SUBSTANCE : invention relates to medicine, namely to pharmacology. Use of sodium salt of 11H-indeno[1, 2-b]quinoxalin-11-one-oxime as a neuroprotective agent with antioxidant properties and the donator of nitric oxide has been proposed. Technical effect : the use of sodium salt of 11H-indeno[1, 2-b]quinoxaline-11-one-oxime among mice with ischemia/reperfusion of the brain reduces the size of the focus of necrosis and the degree of neurological deficit, increases blood levels of nitric oxide; by antioxidant activity, the compound is not inferior to the reference ionol preparation.EFFECT : invention can be used to treat cerebrovascular diseases.1 cl, 4 tbl, 8 ex |
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