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专利概况
专利名称 NEUROPROTECTIVE MEANS, HAVING THE PROPERTIES OF ANTIOXIDANT AND NITRIC OXIDE DONATOR
申请号 RU2016127070 申请日
公开(公告)号 RU2680526C1 公开(公告)日 2016-07-05
申请(专利权)人 发明人 Shchepetkin Igor Aleksandrovich; Atochin Dmitrij Nikolaevich; Khlebnikov Andrej Ivanovich; Plotnikov Mark Borisovich; Chernysheva Galina Anatolevna; Smolyakova Vera Ivanovna
专利来源 国家知识产权局 转化方式
摘要

FIELD : medicine.SUBSTANCE : invention relates to medicine, namely to pharmacology. Use of sodium salt of 11H-indeno[1, 2-b]quinoxalin-11-one-oxime as a neuroprotective agent with antioxidant properties and the donator of nitric oxide has been proposed. Technical effect : the use of sodium salt of 11H-indeno[1, 2-b]quinoxaline-11-one-oxime among mice with ischemia/reperfusion of the brain reduces the size of the focus of necrosis and the degree of neurological deficit, increases blood levels of nitric oxide; by antioxidant activity, the compound is not inferior to the reference ionol preparation.EFFECT : invention can be used to treat cerebrovascular diseases.1 cl, 4 tbl, 8 ex

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