The present disclosure relates to a column chromatographic method of manufacturing non-carrier-added high-purity 177Lu compounds for medicinal purposes. In the method in accordance with the disclosure a cation exchanger and a suitable chelating agent are used. With the method in accordance with the disclosure it is possible to provide non-carrier-added high-purity 177Lu compounds in milligram amounts for pharmaceutical-medicinal purposes from 176Yb compounds irradiated with thermal neutrons, the radionuclides 177Lu and 176Yb being present in an approximate mass ratio of 1 : 102 to 1 : 1010 for purification.