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专利概况
专利名称 GLP-a 1 derivative and its use
申请号 JP2016520494 申请日
公开(公告)号 JP6475233B2 公开(公告)日 2014-06-19
申请(专利权)人 发明人 ステフェン・リードッツ ルンゲ; ペル・サウアーベア; ヤコブ・コフォード; イングリッド・ペッタソン; クリスティアン・ヴェンゼル・トーヌー
专利来源 国家知识产权局 转化方式
摘要

The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.

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