Provided are a long-acting rasagiline prodrug and a preparation method and use thereof. The long-acting rasagiline prodrug has a structure of formula (I), wherein, T is selected from (II) or not present; R1 and R2 are each independently selected from hydrogen, deuterium, and methyl; W is selected from (CH2)n or does not exist, n is selected from an integer from 1 to 15; X is selected from (CH2)m or not present, m is selected from an integer from 1 to 10; Y is selected from -C(=O)NH-, -NHC(=O)- or not present; R3 is selected from substituted or unsubstituted C1-C30 alkyl, substituted or unsubstituted C2-C30 alkenyl, substituted or unsubstituted C2-C30 alkynyl, substituted or unsubstituted C3-C30 cycloalkyl, cholane fatty chain, -R3a-C(＝O)O-R3b, -R3a-OC(＝O)-R3b, -R3a-C(＝O)NH-R3b, -R3a-NHC(＝O)-R3b, or -R3a-S(＝O)1-2O-R3b and -R3a-OS(＝O)1-2-R3b； The rasagiline prodrug provided has a high melting point and low solubility, and can form a drug depot in the body after being prepared into an injection and administered, thereby prolonging the release of the drug in the body and achieving a long-term treatment.