专利名称 | AEROSOL TYROSINE KINASE INHIBITOR COMPOUNDS AND USES THEREOF | ||
申请号 | JP2018187766 | 申请日 | |
公开(公告)号 | JP2019031514A | 公开(公告)日 | 2018-10-02 |
申请(专利权)人 | 发明人 | MARK WILLIAM SURBER | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide liquid, dry powder and metered-dose formulations for therapeutic inhaled delivery of phenylaminopyrimidine derivative compositions such as imatinib and other kinase inhibitor compounds to desired anatomical sites, for treatment and/or prophylaxis of a variety of pulmonary, neurologic, cardiovascular and solid organ disease conditions. SOLUTION : An aqueous solution for nebulized inhalation administration comprises : water; imatinib or a salt thereof, a phenylaminopyrimidine derivative or a salt thereof, or another tyrosine kinase inhibitor or a salt thereof, at a concentration from about 0.001 mg/mL to about 200 mg/mL; where the osmolality of the aqueous solution is from about 50 mOsmol/kg to about 2000 mOsmol/kg. SELECTED DRAWING : Figure 1 COPYRIGHT : (C)2019, JPO&INPIT |
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