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专利概况
专利名称 AEROSOL TYROSINE KINASE INHIBITOR COMPOUNDS AND USES THEREOF
申请号 JP2018187766 申请日
公开(公告)号 JP2019031514A 公开(公告)日 2018-10-02
申请(专利权)人 发明人 MARK WILLIAM SURBER
专利来源 国家知识产权局 转化方式
摘要

PROBLEM TO BE SOLVED : To provide liquid, dry powder and metered-dose formulations for therapeutic inhaled delivery of phenylaminopyrimidine derivative compositions such as imatinib and other kinase inhibitor compounds to desired anatomical sites, for treatment and/or prophylaxis of a variety of pulmonary, neurologic, cardiovascular and solid organ disease conditions. SOLUTION : An aqueous solution for nebulized inhalation administration comprises : water; imatinib or a salt thereof, a phenylaminopyrimidine derivative or a salt thereof, or another tyrosine kinase inhibitor or a salt thereof, at a concentration from about 0.001 mg/mL to about 200 mg/mL; where the osmolality of the aqueous solution is from about 50 mOsmol/kg to about 2000 mOsmol/kg. SELECTED DRAWING : Figure 1 COPYRIGHT : (C)2019, JPO&INPIT

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