| 专利名称 | IMPROVED HUMAN HERPESVIRUS IMMUNOTHERAPEUTIC PROTEIN | ||
| 申请号 | JP2018207238 | 申请日 | |
| 公开(公告)号 | JP2019030331A | 公开(公告)日 | 2018-11-02 |
| 申请(专利权)人 | 发明人 | RAJIV KHANNA; DASARI VIJAYENDRA | |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
PROBLEM TO BE SOLVED : To provide a protein for human herpesvirus immunotherapy. SOLUTION : An isolated protein includes amino acid sequences respectively corresponding to a plurality of CTL epitopes derived from 2 or more different herpesvirus antigens, and further includes, between at least 2 of the CTL epitopes, an interposing amino acid or amino acid sequence comprising a proteasome releasing amino acid or amino acid sequence and an optional recognition motif for transporter associated with antigen processing (TAP). The isolated protein may quickly increase human cytotoxic T lymphocyte (CTL) in vitro and elicit CTL immuno response upon being administered to animals as exogenous protein in vivo. SELECTED DRAWING : Figure 1 COPYRIGHT : (C)2019, JPO&INPIT |
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