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专利概况
专利名称 IMPROVED HUMAN HERPESVIRUS IMMUNOTHERAPEUTIC PROTEIN
申请号 JP2018207238 申请日
公开(公告)号 JP2019030331A 公开(公告)日 2018-11-02
申请(专利权)人 发明人 RAJIV KHANNA; DASARI VIJAYENDRA
专利来源 国家知识产权局 转化方式
摘要

PROBLEM TO BE SOLVED : To provide a protein for human herpesvirus immunotherapy. SOLUTION : An isolated protein includes amino acid sequences respectively corresponding to a plurality of CTL epitopes derived from 2 or more different herpesvirus antigens, and further includes, between at least 2 of the CTL epitopes, an interposing amino acid or amino acid sequence comprising a proteasome releasing amino acid or amino acid sequence and an optional recognition motif for transporter associated with antigen processing (TAP). The isolated protein may quickly increase human cytotoxic T lymphocyte (CTL) in vitro and elicit CTL immuno response upon being administered to animals as exogenous protein in vivo. SELECTED DRAWING : Figure 1 COPYRIGHT : (C)2019, JPO&INPIT

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