The present application discloses an antibody or an antigen-binding moiety thereof that specifically binds to human CD47, a polynucleotide encoding the antibody or the antigen-binding moiety thereof, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, a method for preparing and purifying the antibody, and an application of the antibody or the antigen-binding moiety thereof.