Provided in the present invention is the use of a verbascoside in the preparation of a drug for preventing or treating glomerular podocyte injured renal disease, belonging to the field of medicine. The inventors found that the verbascoside can effectively restore the viability of glomerular podocytes, reduce the abnormal migration ability thereof, protect the cytoskeletons of the podocytes, and restore the expression levels of podocyte injury markers, i.e. nephrin protein and synaptopodin protein, thereby significantly reducing urinary protein. Therefore, the verbascoside can be applied to prepare drugs or healthcare products for preventing or treating diseases associated with glomerular podocyte injury, alone or in combination with other drugs, and to prepare drugs or healthcare products for alleviating damage to podocytes caused by other drugs, thereby providing new treatment means and ideas for diseases caused by glomerular podocyte injury.