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专利概况
专利名称 VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER
申请号 US16069221 申请日
公开(公告)号 US20190077767A1 公开(公告)日 2017-01-12
申请(专利权)人 发明人 Hiroto TANAKA; Isao OOI; Yuzo MOGI; Masaaki HIROSE; Tsuyoshi ENDO; Toru OGAWA; Atsufumi KAWABATA
专利来源 国家知识产权局 转化方式
摘要

A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker : wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2, provide that n and m are not 0 and 2 at the same time.

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