专利名称 | The diamide macrocycle ring having inhibitory activity against factor XIA | ||
申请号 | JP2018545880 | 申请日 | |
公开(公告)号 | JP2019507167A | 公开(公告)日 | 2017-03-01 |
申请(专利权)人 | 发明人 | シ・ジュン; ウィリアム・アール・ユーイング; ドナルド・ジェイ・ピー・ピント | |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention provides compounds of Formula (I) : or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. |
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