PROBLEM TO BE SOLVED : To provide compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins. SOLUTION : The invention provides 4-(4-{[2-(4-chlorophenyl)-4, 4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-1, 4-dioxan-2-ylmethyl]amino}-3-nitrophenyl)sulfonyl]-2-(1H-pyrrolo[2, 3-b]pyridin-5-yloxy)benzamide, and the like; and pharmaceutically acceptable salts, prodrugs, metabolites and salts of the prodrugs thereof. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT