FIELD : medicine.SUBSTANCE : group of inventions relates to medicine. Methods are described associated with regenerative medicine, for the treatment of lesions of cartilage, osteoarthritis and cartilage damage, in particular. FGF-18 compound is described for use in tissue engineering and transplantation procedures, such as bone cartilage or cartilage grafts, or autologous chondrocyte implantation (ACI).EFFECT : compound FGF-18 has a beneficial effect on three-dimensional cultures.11 cl, 11 dwg, 5 ex