A drug delivery device includes a housing having a rigid base with a surface defining at least one pressure communication channel or aperture, which distributes a negative fluid pressure across the base that draws the tissue against the base. The device may further include a porous, adhesive layer disposed over the pressure communication channel(s) or aperture(s), for adhesively attaching the device to tissue, which distribute a negative fluid pressure across the adhesive layer, to draw the tissue against the adhesive layer. The device may further include a pressure sensor for determining whether the device is properly attached to the body tissue by the adhesive layer. Further, at least one bladder may be used instead of the porous, adhesive layer for adhesively attaching the device to tissue. The bladder, in a partially inflated or expanded state, can apply constant pressure across the contact surface as it conforms to the contour of the tissue when the device is applied to the tissue thereby causing a flexible adhesive layer attached to the bottom thereof to conform to the contour of the tissue and adhere thereto. The subsequent evacuation of the bladder causes it to deflate and collapse or retract against the base, thereby causing the flexible adhesive layer, which is adhered to the tissue, to pull the tissue toward the base, thereby stretching the tissue.