FIELD : veterinary medicine.SUBSTANCE : invention relates to the field of medicine, namely to veterinary virology and biotechnology, and can be used to obtain an inactivated emulsion vaccine for O-type aphthous fever. Vaccine inactivated emulsion for O-type aphthous fever contains avirulent and purified antigenic material from the virus strain of Picornaviridae family, Aphtovirus genus, Aphtae epizooticae species, O type, SEA topology, Mua-98 genetic line, deposited in the Collection of microorganism strains of the Federal Centre for Animal Health (FGBI ARRIAH), under registration number (link) : VYa O No. 2212/Primorsky/2014 strain (production), in an effective amount.EFFECT : vaccine has high immunogenicity and is able to provide effective protection against the homologous infectious agent circulating in the countries of Southeast and Central Asia, the Far East.10 cl, 1 dwg, 8 ex, 9 tbl