The present invention relates to a paclitaxel pharmaceutic composition and a pharmaceutic preparation, a preparation process therefor and use thereof. The paclitaxel composition comprises paclitaxel as an active ingredient and hydroxypropyl methyl cellulose derivative as a carrier material. The paclitaxel preparation is in the form of an oral solid preparation. The paclitaxel composition and pharmaceutic preparation thereof can be used for the preparation of a drug for preventing and treating malignancies and relevant diseases in mammals.