PROBLEM TO BE SOLVED : To provide a novel medicine for treating endometriosis or uterine adenomyosis using no hormonal therapy, and to provide a screening method of the novel medicine for treating endometriosis or uterine adenomyosis. SOLUTION : Provided are a medicine for treating endometriosis or uterine adenomyosis which contains a MyD88-IRAK4 signal transduction pathway inhibitor, and a screening method of a medicine for treating endometriosis or uterine adenomyosis which uses an activation state of MyD88-IRAK4 signal transduction pathway as an index. SELECTED DRAWING : Figure 4 COPYRIGHT : (C)2019, JPO&INPIT