专利名称 | With respect to EGFR chimeric antibodies for treatment of cancer with improved safety glycosylation | ||
申请号 | JP2018535857 | 申请日 | |
公开(公告)号 | JP2019508380A | 公开(公告)日 | |
申请(专利权)人 | Sorrento Therapeutics Inc | 发明人 | ジアン・ツァオ; ジェフリー・スー |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
There is disclosed a chimeric cetuximab-like monoclonal antibody (CMAB009 mAb) having at least 80% NANA glycosylation terminal sialic acid at an N-glycosylation site Asn297 and a glycosylation pattern of Gal-α(2, 3/6)-Gal. The disclosed CMAB009 monoclonal antibody is a chimeric antibody having the same amino acid sequence (light chain/heavy chain of SEQ ID NO. 1/SEQ ID NO. 3) as cetuximab (Erbitux®) which has at least 80% NGNA terminal sialic acid and a glycosylation pattern of Gal-α(1, 3)-Gal. |
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