PROBLEM TO BE SOLVED : To provide novel compounds that are useful in regulating the expression of interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). SOLUTION : The present invention provides a compound of the following formula. [In the formula, Q and V are independently selected from CH and nitrogen; U is selected from C=O, C=S, SO2, S=O, SR1, CR1R2, CR1OR2, and CR1SR2]. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT