The invention relates to the field of medicine, and more particularly to psychopharmacology and psychoneurology. A combination of drugs comprising various active agents, which do not have a direct analgesic effect, in conjunction with one or more pharmaceutically acceptable vehicles, is provided for treating disorders associated with pain symptoms. The composition makes it possible to increase the effectiveness of treatment by virtue of the reduced dosage of drugs comprised in the composition, more particularly Mirtazapine (INN) and Tizanidine (INN), required for achieving the desired therapeutic effect.