Compositions and methods for treatment, control, or prevention of skin conditions or skin diseases associated with microbial biofilms are provided. A topical formulation comprises a surfactant, pharmaceutically acceptable carrier, biocide, and weak acid and is effective to disrupt both the microbial biofilm defenses as well as the microbes within. The topical formulation is also provided as a multi-component system suitable for the application to human or animal skin or mucosa. Methods of administering the topical formulations to an individual having, or at risk for having, a skin disease or skin condition associated with a microbial biofilm are also disclosed.