The invention relates to nucleic acids including lentiviral vectors and lentiviral vector particles encoding at least one Hepatitis B virus (HBV) envelop surface of genotypes A and/or C antigen at least one polymerase of genotypes A and/or C antigen at least one HBX protein of genotypes A and/or C antigen at least one HBV consensus core of genotypes A and/or C antigen and at least one HBV consensus core MHCI and MHCII epitopes of genotypes A and/or C antigen. The invention encompasses these lentiviral vectors and lentiviral vector particles methods of making the vectors and their use including medicinal uses. The lentiviral vectors and lentiviral vector particles are for use in administering to humans to induce immune responses against the HBV antigens.