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专利概况
专利名称 2, 3-dihydro-1H-imidazo{1, 2-a}pyrimidin-5-one and this 1, 2, 3, 4-tetrahydropyrimido{1, 2-a}pyrimidin-6-one derivatives comprising a substituted morpholine, preparation thereof and pharmaceutical use thereof
申请号 US14409964 申请日
公开(公告)号 US10253043B2 公开(公告)日
申请(专利权)人 SANOFI 发明人 Youssef El Ahmad; Bruno Filoche Romme; Jean Philippe Letallec; Gilbert Marciniak; Baptiste Ronan; Bertrand Vivet; Maurice Brollo
专利来源 国家知识产权局 转化方式
摘要

The invention relates to the novel products of formula (I) with p, q=0, 1 or 2; R1=phenyl, pyridyl; —(CH2)m—Ra; alkylene; cycloalkyl; heterocycloalkyl; alkyl; —SO2 —Rb; —CO—Re; m=1 or 2; Ra=aryl, heteroaryl, —CO-cycloalkyl, —CO-heterocycloalkyl, —CO—Rb, —C(Rb)═N—ORc, —CO 2 Rd, —CONRxRy; Rb=alkyl, aryl, heteroaryl; Rc=H, alkyl; Rd=alkyl, cycloalkyl; Re=alkyl, cycloalkyl, aryl, heteroaryl; NRxRy with Rx, Ry=H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N; R2, R3=H, alkyl, CF 3, or form with C a ring with optionally O, S and N; R4=H, F, Cl, CH3 or CN; the morpholine is substituted with Me, and optionally substituted with F, OH; or is (Formula 1a) and the isomer of configuration R, R (Formula 1b) these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.

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