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专利概况
专利名称 LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS
申请号 JP2018248768 申请日
公开(公告)号 JP2019056006A 公开(公告)日
申请(专利权)人 EAGLE BIOLOGICS INC 发明人 ALYSSA M LARSON; KEVIN LOVE; ALISHA K WEIGHT; ALAN CRANE; LANGER ROBERT S; ALEXANDER M KLIBANOV
专利来源 国家知识产权局 转化方式
摘要

To provide concentrated, low-viscosity liquid formulations of proteins, especially high-molecular-weight proteins, such as mAbs, capable of delivering therapeutically effective amounts of these proteins in volumes useful for SC and IM injections.SOLUTION : A liquid pharmaceutical formulation for injection comprises (i) antibodies, (ii) one or more viscosity-lowering agents, and (iii) a pharmaceutically acceptable solvent. When in a volume suitable for injection, the liquid pharmaceutical formulation has an absolute viscosity from about 1 cP to about 100 cP at 25癈 as measured using a cone and plate viscometer or microfluidic viscometer. The absolute viscosity of the liquid pharmaceutical formulation is less than the absolute viscosity of a control composition comprising the antibodies and the pharmaceutically acceptable solvent and not comprising the one or more viscosity-lowering agents, where each absolute viscosity is an extrapolated zero-shear viscosity.SELECTED DRAWING : None

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