专利名称 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | ||
申请号 | JP2018248768 | 申请日 | |
公开(公告)号 | JP2019056006A | 公开(公告)日 | |
申请(专利权)人 | EAGLE BIOLOGICS INC | 发明人 | ALYSSA M LARSON; KEVIN LOVE; ALISHA K WEIGHT; ALAN CRANE; LANGER ROBERT S; ALEXANDER M KLIBANOV |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
To provide concentrated, low-viscosity liquid formulations of proteins, especially high-molecular-weight proteins, such as mAbs, capable of delivering therapeutically effective amounts of these proteins in volumes useful for SC and IM injections.SOLUTION : A liquid pharmaceutical formulation for injection comprises (i) antibodies, (ii) one or more viscosity-lowering agents, and (iii) a pharmaceutically acceptable solvent. When in a volume suitable for injection, the liquid pharmaceutical formulation has an absolute viscosity from about 1 cP to about 100 cP at 25癈 as measured using a cone and plate viscometer or microfluidic viscometer. The absolute viscosity of the liquid pharmaceutical formulation is less than the absolute viscosity of a control composition comprising the antibodies and the pharmaceutically acceptable solvent and not comprising the one or more viscosity-lowering agents, where each absolute viscosity is an extrapolated zero-shear viscosity.SELECTED DRAWING : None |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017