To provide innovative compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels.SOLUTION : In one aspect, described herein is a pyridine or pyrazine derivative represented by Formula (I) : (X being CRor N; Rbeing H, a halogen, Cto Calkyl, or others; Lbeing O, S or NR; Rbeing H, Cto Calkenyl or Cto Calkyl; Lbeing -NH-C(=O)-, or -C(=O)NH-; Rbeing aryl or heteroaryl optionally substitutable; Rbeing Cto Calkyl or others; and n being 0, 1, or 2).SELECTED DRAWING : Figure 1