专利名称 | PHARMACEUTICAL TABLETS CONTAINING ERLOTINIB AS ACTIVE INGREDIENT | ||
申请号 | JP2017184473 | 申请日 | |
公开(公告)号 | JP2019059685A | 公开(公告)日 | |
申请(专利权)人 | NIPPON KAYAKU KK | 发明人 | AOKI SUSUMU |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
To provide a pharmaceutical tablet containing as an active ingredient erlotinib hydrochloride that accelerate the elution of an active ingredient in a neutral medium, such as water and has quick disintegrability.SOLUTION : A pharmaceutical formulation using an active ingredient compounded with A and B crystalline polymorphisms of erlotinib hydrochloride and further using a binder and a disintegrant exerted the elution of 25% or more in 30 minutes, preferably 40% or more in 30 minutes in the dissolution test with water according to the Japanese Pharmacopoeia Dissolution Test Method 2 (paddle method), and a tablet having disintegratability of tablets within 3 minutes in water according to the Japanese Pharmacopoeia disintegration test was obtained.SELECTED DRAWING : None |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
版权所有:海南商业联合会 | 备案号:粤ICP备13083911号(ICP加挂服务)@2017