FIELD : biotechnology.SUBSTANCE : invention refers to biotechnology, microbiology and molecular genetics. Disclosed is a chimeric recombinant protein consisting of conservative and immunogenic fragments of amino acid sequences of surface proteins Streptococcus pyogenes : Sic, SpySEP, SpeA, ScpA, ScaAB and terminal domains of flagellin Salmonella typhiurium FliA and FliC, which serve as internal adjuvant. Declared protein induces in vivo synthesis of class G antibodies specific to said chimeric protein and having protective properties with respect to Streptococcus pyogenes.EFFECT : invention can be used in medical industry when producing Streptococcus pyogenes group A streptococcus vaccines (SGA).1 cl, 2 dwg, 3 ex