专利名称 | Production of antibodies | ||
申请号 | JP2017020965 | 申请日 | |
公开(公告)号 | JP6506786B2 | 公开(公告)日 | |
申请(专利权)人 | 中外製薬株式会社 | 发明人 | 山田 良樹; 喜安 達也; 田畑 和之; 葛巻 章浩; 山城 舞 |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant. |
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