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专利概况
专利名称 Production of antibodies
申请号 JP2017020965 申请日
公开(公告)号 JP6506786B2 公开(公告)日
申请(专利权)人 中外製薬株式会社 发明人 山田 良樹; 喜安 達也; 田畑 和之; 葛巻 章浩; 山城 舞
专利来源 国家知识产权局 转化方式
摘要

The present invention provides a method of producing a recombinant antibody efficiently and at low cost. Disclosed is a method of producing an antibody or a fragment thereof, comprising allowing a cell to produce the antibody or the fragment, wherein the cell contains a larger number of copies of an exogenous DNA encoding the light chain or a fragment thereof of the antibody than the number of copies contained in the cell of an exogenous DNA encoding the heavy chain or a fragment thereof of the antibody. The present invention also provides a recombinant vector comprising one copy of a DNA encoding the heavy chain or a fragment thereof of an antibody and two or more copies of a DNA encoding the light chain or a fragment thereof of the antibody; and a transformant.

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