专利名称 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ||
申请号 | WOCN18110795 | 申请日 | |
公开(公告)号 | WO2019076336A1 | 公开(公告)日 | |
申请(专利权)人 | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD; SHANGHAI HANSOH BIOMEDICAL CO LTD | 发明人 | LIU Shiqiang; ZHOU Yuanfeng; LIU Yang; WU Xuesong; LIU Lei; BAO Rudi |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present invention relates to a pyrazolyl-containing tricyclic derivative, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protease such as ERK (MAPK) inhibitor in the treatment of cancers, bone diseases, inflammatory diseases, immune diseases, nervous system diseases, metabolic diseases, respiratory diseases and heart diseases, wherein the definition of each substituent in the general formula (I) is the same as defined in the description. |
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