The invention belongs to the field of medicine, involving new uses of Paliurus ramosissimus (Lour.) Poir. and its extract, in particular the use of Paliurus ramosissimus (Lour.) Poir. and its extract in preparation of drugs with anti-fibrotic, anti-fungal, and anti-tumor activities, for the treatment of oral and digestive tract inflammation or (and) ulcer-related diseases, or with bi-directional immunomodulatory effects.