The present invention relates to a pharmaceutical combination which may be useful for the treatment of diseases which involve cell proliferation, especially metastatic colorectal cancer comprising 3-Z-[1-(4-(N-((4-methyl-piperazin-l-yl)-methylcarbonyl)- N-methyl-amino)-anilino)- 1 -phenyl-methylene] -6-methoxycarbonyl-2-indo lino ne or a pharmaceutically acceptable salt thereof, and 2' -deoxy-5-(trifluoromethyl)uridine or a pharmaceutically acceptable salt thereof, and 5-chloro-6-[(2-iminopyrrolidin-l- yl)methyl]pyrimidine-2, 4(lH, 3H)-dione or a pharmaceutically acceptable salt thereof, wherein the molar ratio of 2' -deoxy-5-(trifluoromethyl)uridine or a pharmaceutically acceptable salt thereof, and 5-chloro-6-[(2-iminopyrrolidin-l-yl)methyl]pyrimidine- 2, 4(1H, 3H)-dione or a pharmaceutically acceptable salt thereof, is 1 : 0.5