专利名称 | Practical method for manufacturing 3, 3-difluoro-2-hydroxypropionic acid | ||
申请号 | US15551640 | 申请日 | |
公开(公告)号 | US10273200B2 | 公开(公告)日 | |
申请(专利权)人 | Central Glass Company Limited | 发明人 | Takako Yamazaki; Ryuichi Okamoto; Akihiro Ishii |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
Disclosed is a practical method for production of 3, 3-difluoro-2-hydroxypropionic acid, which is important as pharmaceutical and agrichemical intermediates. The method includes forming a 4, 4-difluoro-2, 2-dichloro-3-oxobutanoic acid ester by reaction of a 4, 4-difluoro-3-oxobutanoic acid ester with chlorine (Cl2), forming 3, 3-difluoro-1, 1-dichloro-2-propanone by reaction of the chlorination product with an acid, and then, reacting the degradation product with a basic aqueous solution. |
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