专利名称 | USE OF N-(6, 8, 8-TRIMETHYL-8, 9-DIHYDROFURO[3, 2-H]QUINOLIN-5-YL)ACETAMIDE AS AN AGENT FOR PHOTOTHERAPY OF PSORIASIS AND PSORIATIC ARTHRITIS | ||
申请号 | RU2018123743 | 申请日 | |
公开(公告)号 | RU2686692C1 | 公开(公告)日 | |
申请(专利权)人 | Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie nauki Institut biokhimicheskoj fiziki im N M Emanuelya Rossijskoj akademii nauk (IBKHF RAN) (RU) | 发明人 | Shevelev Aleksej Borisovich; Kuzmin Vladimir Aleksandrovich; Nekipelova Tatyana Dmitrievna; Khodot Evgenij Nikiforovich; Biryukova Yuliya Konstantinovna; Zylkova Marina Valerevna; Trubnikova Elena Vladimirovna; Kriushkina Olga Nikolaevna; Mutnykh Elena Sergeevna; Volnukhin Vladimir Anatolevich |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
FIELD : medicine; pharmaceuticals.SUBSTANCE : invention refers to medical chemistry, pharmaceutics and dermatology and can be used for phototherapy of psoriasis and psoriatic arthritis. Disclosed is the use of N-(6, 8, 8-trimethyl-8, 9-dihydrofuro[3, 2-h]quinoline-5-yl)acetamide as a skin-acting photosensitizer for treating psoriasis and psoriatic arthritis by PUVA therapy.EFFECT : use of N-(6, 8, 8-trimethyl-8, 9-dihydrofuro[3, 2-h]quinolin-5-yl)acetamide in combination with irradiation with long-wave ultraviolet light reduced skin hyperkeratosis and lymphocyte content of Th17-type and production of IL-17 and IL-23 lymphokines (key biological markers of psoriatic skin lesions) with efficacy not lower than authorized ammifurin preparation with low toxicity in intragastric and ocular administration; in contrast to ammifurin it is effective both at subminimal, and at minimum phototoxic doses.3 cl, 4 dwg, 8 tbl |
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