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专利概况
专利名称 Dinuclear compound bis(m2-1-(7-chloro-6-methyl-2, 3-bis(pyridin-2-yl)-5H-cyclopenta[b]pyrazin-5-yl)ethanone)-dichloro-di-copper(II) methanol solvate
申请号 MD20170091 申请日
公开(公告)号 MD20170091A2 公开(公告)日
申请(专利权)人 INST DE FIZICA APLICATA AL ACADEMIEI DE STIINTE A MOLDOVEI 发明人 MELNIC ELENA; KRAVŢOV VICTOR; BACA SVETLANA
专利来源 国家知识产权局 转化方式
摘要

The invention relates to the chemistry of coordinative compounds, to metal-organic complex compounds of copper(II) with pyrazine and pyridine derivatives, in particular to the class of 2, 3-bis(2-pyridyl)pyrazine. Due to their antimicrobial and antitumor activity, these compounds may be promising candidates for use in medicine.Summary of the invention consists in developing an optimal process for producing a new coordinative dinuclear compound of copper(II) [Cu2(acdpp)2Cl2]?(CH3OH), which contains a unique ligand 1-(7-chloro-6-methyl-2, 3-bis(pyridin-2-yl)-5H-cyclopenta[b]pyrazin-5-yl)ethanone) (acdpp)-, obtained by condensation of 2, 3-bis(2-pyridyl)pyrazine and acetylacetone ligands.The process for producing this compound consists in dissolving copper(II) chloride dihydrate and 2, 3-bis(2-pyridyl)pyrazine in methanol with subsequent addition of acetylacetone. Slow evaporation of this solution leads to the growth of single crystals of the target product [Cu2(acdpp)2Cl2]?(CH3OH).

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