Medicine intermediates 2, 6-dicarboxylic acid pyridine synthesis method, comprises the following steps : 2 mol 2-isopropyl-3, 5-dihydroxy-6-ethylpyridine and 5-7 mol ethylene glycol methyl ether were added to the reaction vessel, controlled the stirring rate at 190-230 rpm, raised the temperature to 60-67 V, added 3-4mol bismuth trichloride, kept for 40-60 min, reduced the temperature of the solution to 5-9 V, precipitated the solid, filtrated, washed with potassium nitrate solution for 3-7 times, combined the filtrate and washing solution, controlled the stirring speed at 110-130 rpm, adjusted the pH to 2-3 by oxalic acid solution, washed with N-benzylmethylamine solution, washed with benzyl methyl ether solution, recrystallized in propyl phenyl ketone solution, precipitated the crystals, got the finished product 2, 6-dicarboxylic acid pyridine.