The present invention is a method of producing a 2' -trifluoromethyl-substituted aromatic ketone comprising reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2' -trifluoromethyl-substituted aromatic ketone. The method of producing a 2' -trifluoromethyl-substituted aromatic ketone of the present invention enables 2' -trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2' -trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2' -trifluoromethyl-substituted aromatic ketone of the present invention can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.