The present invention relates to a polysubstituted pyridone derivative, a preparation method therefor and a medical use thereof. In particular, involved are a polysubstituted pyridone derivative as shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of same as an Axl/c-MET inhibitor in the treatment of cancers, wherein the definitions of each group in general formula (I) are the same as those in the description.