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专利概况
专利名称 3, 4-bipyridyl pyrazole derivative, and preparation method therefor and medical application thereof
申请号 AU2017357333 申请日
公开(公告)号 AU2017357333A1 公开(公告)日
申请(专利权)人 Jiangsu Hengrui Medicine Co Ltd; Shanghai Hengrui Pharmaceutical Co Ltd 发明人 Yang Fanglong; Zhang Ling; Shen Guangyuan; He Feng; Tao Weikang
专利来源 国家知识产权局 转化方式
摘要

The present invention relates to a 3, 4-bipyridyl pyrazole derivative, and a preparation method therefor and a medical application thereof. Specifically, the present invention relates to a new 3, 4-bipyridyl pyrazole derivative as shown in formula (I), a preparation method for the derivative, a pharmaceutical composition containing the derivative, a use of the derivative as a therapeutic agent, in particular as a TGF-β inhibitor, and a use of the derivative in the preparation of a drug which treats, prevents or reduces cancer mediated by TGF-β overexpression. The substituents in formula (I) have the same definitions as in the description.

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