FIELD : medicine; pharmaceuticals.SUBSTANCE : invention refers to pharmaceutics and medicine, namely to an antimicrobial pharmaceutical composition in the form of effervescent tablets containing nitrofural. Composition contains as an active substance nitrofural, as auxiliary substances sodium chloride, gas-forming mixture, acidity regulator and binder, in quantities specified in the patent claim. Effervescent tablets of nitrofural are prepared by wet granulation. Antimicrobial composition may optionally contain a lubricant and sodium lauryl sulphate.EFFECT : invention provides wider range of antimicrobial medicinal agents, high granulation effluent for tableting and high strength of tablets for crushing.14 cl, 4 tbl, 12 ex