| 专利名称 | Can sill acid salt | ||
| 申请号 | JP2018021595 | 申请日 | |
| 公开(公告)号 | JP6509393B2 | 公开(公告)日 | |
| 申请(专利权)人 | ASTRAZENECA AKTIEBOLAG | 发明人 | マーティン・ハンス・ボーリン; クレイグ・ロバート・スチュアート |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
A process for the preparation of a camsylate salt ((1S)-(+)-10 camphorsulfonic acid) of (1r, 1' R, 4R)- 4-methoxy-5"-methyl-6' -[5-(prop-1-yn-1-yl)pyridin- 3-yl]-3' H-dispiro[cyclohexane-1, 2' -inden-1' 2' -imidazole]-4"-amine is disclosed as well as pharmaceutical compositions containing the salt and therapeutic uses of the salt for treating A?related pathologies such as Alzheimer' s Disease, Down' s Syndrome, ?amyloid angiopathy and conditions such as dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson' s Disease, progressive supranuclear palsy or cortical basal degeneration. |
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