PROBLEM TO BE SOLVED : To provide methods for treating or preventing cancer. SOLUTION : Disclosed herein is a method comprising using an effective amount of a TOR kinase inhibitor represented by formula (I) in combination with an effective amount of a receptor tyrosine kinase inhibitor, a phosphoinositide 3-kinase pathway inhibitor, a serine/threonine-protein kinase and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase pathway inhibitor, a DNA damaging agent, a DNA damage response agent, a cytoskeleton perturbagen, a protein stability inhibitor a Bruton' s tyrosine kinase inhibitor or a Bcl-2 protein family inhibitor. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT