| 专利名称 | PYRIMIDINONES AS FACTOR XIA INHIBITORS | ||
| 申请号 | JP2018244086 | 申请日 | |
| 公开（公告）号 | JP2019069989A | 公开（公告）日 | |
| 申请（专利权）人 | BRISTOL MYERS SQUIBB COMPANY | 发明人 | ANDREW K DILGER; JAMES R CORTE; INDAWATI DLUCCA; FANG TIANAN; YANG WU; WANG YUFENG; KUMAR BALASHANMUGA PABBISETTY; WILLIAM R EWING; ZHU YEHENG; RUTH R WEXLER; DONALD J P PINTO; MICHAEL J ORWAT; LEON M SMITH II |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
PROBLEM TO BE SOLVED : To provide selective inhibitors of a serine protease enzyme, in particular, factor XIa and/or plasma kallikrein. SOLUTION : The present invention provides compounds represented by a formula (I) in the figure, or stereoisomers, tautomers or pharmaceutically acceptable salts thereof. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT |
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