PROBLEM TO BE SOLVED : To provide methods and compositions for preventing or treating skeletal muscle infirmities, such as mechanical ventilation (MV)-induced diaphragm muscle weakness, dysfunction and/or atrophy.SOLUTION : The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT