专利名称 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | ||
申请号 | JP2018224084 | 申请日 | |
公开(公告)号 | JP2019069947A | 公开(公告)日 | |
申请(专利权)人 | MedImmune Limited | 发明人 | PHILIP WILSON HOWARD; JOHN A FLYGARE; THOMAS PILLOW; WEI BINQING |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide a conjugate including a pyrrolobenzodiazepine dimer compound having a linker connected to a cell binding agent. SOLUTION : The present invention provides a conjugate compound of formula (A) (where groups of R each have a specific substituent, Y is a substituent including a cell binding agent, Z is CH or N; T and T' are independently selected from a single bond or C1-9 alkylene; X and X' are independently selected from O, S and N(H)). SELECTED DRAWING : None COPYRIGHT : (C)2019, JPO&INPIT |
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