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专利概况
专利名称 Active antibiotic activity against mycobacteria enhanced nitrogen heterocyclic unsaturated N - acylation
申请号 JP2015548640 申请日
公开(公告)号 JP6515035B2 公开(公告)日
申请(专利权)人 ユニベルシテ ドゥ ドロワ エ ドゥ ラ サンテ ドゥ リール 2 发明人 ウィルランド ニコラ; ドゥプレ ブノワ; ボーラード アラン; ブロディン プリシール; フリッポ マリオン; マンゴ リュシー
专利来源 国家知识产权局 转化方式
摘要

The present invention concerns a compound of general formula (I) : in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.

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