| 专利名称 | Active antibiotic activity against mycobacteria enhanced nitrogen heterocyclic unsaturated N - acylation | ||
| 申请号 | JP2015548640 | 申请日 | |
| 公开(公告)号 | JP6515035B2 | 公开(公告)日 | |
| 申请(专利权)人 | ユニベルシテ ドゥ ドロワ エ ドゥ ラ サンテ ドゥ リール 2 | 发明人 | ウィルランド ニコラ; ドゥプレ ブノワ; ボーラード アラン; ブロディン プリシール; フリッポ マリオン; マンゴ リュシー |
| 专利来源 | 国家知识产权局 | 转化方式 | |
| 摘要 |
The present invention concerns a compound of general formula (I) : in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic. |
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