专利名称 | A new minimum UTR sequence | ||
申请号 | JP2018551463 | 申请日 | |
公开(公告)号 | JP2019512260A | 公开(公告)日 | |
申请(专利权)人 | ethris GmbH | 发明人 | クリスチャン プランク; カルステン ルドルフ; マニッシュ クマール アネージャ; ラディック ウェイス |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
Described are DNA molecules which can be transcribed into an mRNA harbouring novel UTR sequences combining the advantages of being extremely short and at the same time allowing for high translation efficiencies of RNA molecules containing them. Further, described are vectors comprising such a DNA molecule and to host cells comprising such a vector. Moreover, described are corresponding RNA molecules containing such UTRs. Further, described in a pharmaceutical composition comprising the described RNA molecule are optionally a pharmaceutically acceptable carrier as well as to the use of the described UTRs for translating a coding region of an RNA molecule into a polypeptide or a protein encoded by said coding region. |
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