专利名称 | T cell regulatory multimeric polypeptide and use thereof | ||
申请号 | JP2018546577 | 申请日 | |
公开(公告)号 | JP2019512222A | 公开(公告)日 | |
申请(专利权)人 | キュー バイオファーマ インコーポレイテッド | 发明人 | ザイデル サード ロナルド ディー; チャパーロ ロドルフォ |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T-cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell; the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure. |
主管部门:海南中小企业服务 | 建设单位:海南商业联合会
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