专利名称 | SOLID PREPARATION CONTAINING 4-AMINOBUTANOIC ACID ANALOG AND PRODUCTION METHOD THEREOF | ||
申请号 | JP2017200996 | 申请日 | |
公开(公告)号 | JP2019073478A | 公开(公告)日 | |
申请(专利权)人 | NIPPON CHEMIPHAR CO LTD | 发明人 | TATSUNO TAKAMITSU; ASHIHARA YUTA; TANIGAWA YUKI; SANO TSUBASA |
专利来源 | 国家知识产权局 | 转化方式 | |
摘要 |
PROBLEM TO BE SOLVED : To provide solid preparations in which drug stability is maintained and generation of the spot on a tablet surface is suppressed, in solid preparations containing 4-aminobutanoic acid analog represented by gabapentin and pregabalin.SOLUTION : Provided is a solid preparation produced by a step of wet-granulation from an emulsified liquid containing γ-aminobutanoic acid analog represented by formula (I), a hardened oil, and glycerine fatty acid ester, and a step of drying, as well as by mixing and tableting with an additive a granule in the state of being coated with a hardened oil and glycerine fatty acid ester.SELECTED DRAWING : NoneCOPYRIGHT : (C)2019, JPO&INPIT |
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