专利 - 详情

专利名称	Quantitative estimate of HAS-and-miR-and-16-and-5p, HAS-and-miR-and-425-and-5p, HAS-and-miR-and-17-and-5p, HAS-and-miR-and-20a-and-5p, HAS-and-miR-and-101-and-3p, HAS-and-miR-and-30d-and-5p and HAS-and-miR-and-93-and-5p in plasma of peripheral blood of women as method of noninvasive diagnosis of serous boundary tsistadenom and tsistadenokartsenom ovary
申请号	RU2018129534	申请日
公开（公告）号	RU2688169C9	公开（公告）日
申请（专利权）人	Federalnoe gosudarstvennoe byudzhetnoe uchrezhdenie "Natsionalnyj meditsinskij issledovatelskij tsentr akusherstva ginekologii i perinatologii imeni akademika V I Kulakova" Ministerstva zdravookhraneniya Rossijskoj Federatsii	发明人	Timofeeva Anzhelika Vladimirovna; Chagovets Vitalij Viktorovich; Asaturova Aleksandra Vyacheslavovna; Sannikova Majya Viktorovna; Khabas Grigorij Nikolaevich; Frankevich Vladimir Evgenevich; Sukhikh Gennadij Tikhonovich
专利来源	国家知识产权局	转化方式
摘要	FIELD : medicine.SUBSTANCE : invention refers to medicine, particularly to oncogynecology, and aims at non-invasive diagnosis of serous adenocystoma borderline and high-grade ovarian cystadenocarcinoma. Disclosed is a quantitative estimate of hsa-miR-16-5p, hsa-miR-425-5p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-101-3p, hsa-miR-30d-5p and hsa-miR-93-5p in peripheral blood plasma of females. Quantitative real-time PCR in a blood plasma sample of a woman is used to determine the level of expression of seven mRNA (hsa-miR-16-5p, hsa-miR-425-5p, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-101-3p, hsa-miR-30d-5p and hsa-miR-93-5p) with preferable use of standard DNA for subsequent calculation of the estimation parameter (EP) when constructing the PLS-DA model. If value is 0 < EP <4.5, a high probability of having a serous ovarian tumour in a woman (serous border cystadene and serous cystadenocarcinoma of high degree of malignancy) is stated. If the value is -1.8 <0 <0, a high probability of serous ovarian tumour absence is stated.EFFECT : invention provides differential diagnosis of serous ovarian tumours with high accuracy and diagnostic significance.1 cl, 12 dwg, 2 ex 1人已参与 0数据匹配